1.
Hamdard Medicus. 2010; 53 (4): 119-123
in English
| IMEMR
| ID: emr-131134
ABSTRACT
2-[3-chlorophenyl]-benzamide was condensed with hydrazine hydrochloride in presence of 10% NaOH to yield 1-[3-chlorophenyl]-4-amino pththalazine [I]. Seven new Schiff bases [II a-g] have been synthesized by the interaction of I with different aromatic aldehyde in dioxane. In final step II was condensed with thioglycolic acid in the presence of acetic acid to yield substituted-2-aryl-3-[4'[1"-3"'-chlorophenyl] phthalazine]]-4-thiazolidione. The synthesized compounds have been characterized by elemental analysis, IR, PMR and Mass spectral analysis and screened for antifungal and insecticidal activity